Assay Detail
Binding
CHEMBL4322964
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Inhibition of human cathepsin L using fluorogenic substrate cbz-FR-AMC monitored for 90 to 120 mins by spectrophotometry
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and <i>Trypanosoma cruzi</i> Cruzain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.53 | 10.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441303 | — | — | 1 | 10.03 |
| CHEMBL4447348 | — | — | 1 | 9.20 |
| CHEMBL4527930 | — | — | 1 | 9.10 |
| CHEMBL4582558 | — | — | 1 | 9.00 |
| CHEMBL4471760 | — | — | 1 | 8.88 |
| CHEMBL4445744 | — | — | 1 | 8.87 |
| CHEMBL4474668 | — | — | 1 | 8.78 |
| CHEMBL4482954 | — | — | 1 | 8.76 |
| CHEMBL4527867 | — | — | 1 | 8.50 |
| CHEMBL4475810 | — | — | 1 | 8.45 |
| CHEMBL4527329 | — | — | 1 | 8.45 |
| CHEMBL4564747 | — | — | 1 | 8.38 |
| CHEMBL541700 | GALLINAMIDE A | — | 1 | 8.33 |
| CHEMBL4457500 | — | — | 1 | 8.18 |
| CHEMBL4514842 | — | — | 1 | 7.11 |
| CHEMBL4468530 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441303 | — | IC50 | = | 0.094 | nM | 10.03 |
| CHEMBL4447348 | — | IC50 | = | 0.632 | nM | 9.20 |
| CHEMBL4527930 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL4582558 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4471760 | — | IC50 | = | 1.31 | nM | 8.88 |
| CHEMBL4445744 | — | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL4474668 | — | IC50 | = | 1.68 | nM | 8.78 |
| CHEMBL4482954 | — | IC50 | = | 1.73 | nM | 8.76 |
| CHEMBL4527867 | — | IC50 | = | 3.13 | nM | 8.50 |
| CHEMBL4475810 | — | IC50 | = | 3.54 | nM | 8.45 |
| CHEMBL4527329 | — | IC50 | = | 3.53 | nM | 8.45 |
| CHEMBL4564747 | — | IC50 | = | 4.15 | nM | 8.38 |
| CHEMBL541700 | GALLINAMIDE A | IC50 | = | 4.67 | nM | 8.33 |
| CHEMBL4457500 | — | IC50 | = | 6.64 | nM | 8.18 |
| CHEMBL4514842 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4468530 | — | IC50 | = | 376.0 | nM | 6.42 |