Assay Detail

CHEMBL4324445

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Displacement of 2-[1251]-iodomelatonin from rabbit parietal cortex melatonin receptor

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Oryctolagus cuniculus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Indole-based melatonin analogues: Synthetic approaches and biological activity.

Wang SY, Shi XC, Laborda P.
Eur J Med Chem (2020) 185 : 111847 -111847
PubMed 31727472 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	3	10.11	10.60

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL289233	IODOMELATONIN	—	1	10.60
CHEMBL33415	—	—	1	10.35
CHEMBL45	MELATONIN	4.0	1	9.39

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL289233	IODOMELATONIN	Ki	=	0.025	nM	10.60
CHEMBL33415	—	Ki	=	0.045	nM	10.35
CHEMBL45	MELATONIN	Ki	=	0.41	nM	9.39