Assay Detail
Functional
CHEMBL4325100
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Antiviral activity against Enterovirus A71 genotype C4 TW/1956/05 infected in human RD cells assessed as reduction in virus-induced cytopathic effect preincubated for 1 day followed by viral infection and measured after 3 days by MTS/PMS method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterovirus A71 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.67 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4468418 | — | — | 1 | 9.70 |
| CHEMBL4538215 | — | — | 1 | 8.85 |
| CHEMBL4520449 | — | — | 1 | 8.70 |
| CHEMBL4451994 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4468418 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4538215 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4520449 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4451994 | — | EC50 | = | 38.0 | nM | 7.42 |