Assay Detail
Functional
CHEMBL4325174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 blood stream forms after 72 hrs by resazurin dye based fluorescence assay
79
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-<i>b</i>]pyridazines for the Treatment of Human African Trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 79 | 6.54 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4548942 | — | — | 1 | 8.30 |
| CHEMBL495696 | GW778894X | — | 1 | 8.20 |
| CHEMBL526110 | — | — | 1 | 8.20 |
| CHEMBL4580246 | — | — | 1 | 7.90 |
| CHEMBL468963 | GW779439X | — | 1 | 7.80 |
| CHEMBL4553256 | — | — | 1 | 7.70 |
| CHEMBL4468068 | — | — | 1 | 7.70 |
| CHEMBL4436808 | — | — | 2 | 7.70 |
| CHEMBL187081 | PYRAZOLOPYRIDAZINE 1 | — | 1 | 7.60 |
| CHEMBL4444383 | — | — | 1 | 7.60 |
| CHEMBL4551743 | — | — | 1 | 7.50 |
| CHEMBL359554 | — | — | 1 | 7.40 |
| CHEMBL4594155 | — | — | 1 | 7.30 |
| CHEMBL359999 | GW801372X | — | 1 | 7.20 |
| CHEMBL4445914 | — | — | 1 | 7.20 |
| CHEMBL4536553 | — | — | 1 | 7.20 |
| CHEMBL4473418 | — | — | 1 | 7.20 |
| CHEMBL361894 | GW806290X | — | 1 | 7.20 |
| CHEMBL4456711 | — | — | 1 | 7.20 |
| CHEMBL4439435 | — | — | 1 | 7.10 |
| CHEMBL4592510 | — | — | 1 | 7.10 |
| CHEMBL4543805 | — | — | 1 | 7.00 |
| CHEMBL4527659 | — | — | 1 | 7.00 |
| CHEMBL4440756 | — | — | 1 | 7.00 |
| CHEMBL4514007 | — | — | 2 | 6.82 |
| CHEMBL4573796 | — | — | 1 | 6.80 |
| CHEMBL4538725 | — | — | 1 | 6.80 |
| CHEMBL4465474 | — | — | 1 | 6.80 |
| CHEMBL364370 | — | — | 1 | 6.80 |
| CHEMBL4556458 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4548942 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL495696 | GW778894X | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL526110 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4580246 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL468963 | GW779439X | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL4436808 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4553256 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4468068 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4436808 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL187081 | PYRAZOLOPYRIDAZINE 1 | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL4444383 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL4551743 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL359554 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4594155 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL4536553 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4456711 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL359999 | GW801372X | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4473418 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4445914 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL361894 | GW806290X | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4592510 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4439435 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4440756 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4527659 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4543805 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4514007 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL364370 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4465474 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4451174 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4514007 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4538725 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4573796 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4556458 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4568663 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4459827 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4458410 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4439547 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4545591 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4437208 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4439027 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL525194 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL495771 | GW708336X | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL4530784 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4470061 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4449705 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4549995 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4573667 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL364587 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4461016 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4474825 | — | EC50 | = | 630.96 | nM | 6.20 |