Assay Detail
Binding
CHEMBL4325293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assay
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.47 | 8.80 |
| pIC50 | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4518946 | — | — | 1 | 8.80 |
| CHEMBL4449047 | — | — | 1 | 8.50 |
| CHEMBL4447804 | — | — | 1 | 8.50 |
| CHEMBL4436797 | — | — | 1 | 8.50 |
| CHEMBL4466265 | — | — | 1 | 8.40 |
| CHEMBL4561242 | — | — | 1 | 8.30 |
| CHEMBL4579923 | — | — | 1 | 8.30 |
| CHEMBL4521647 | — | — | 1 | - |
| CHEMBL4545906 | — | — | 1 | - |
| CHEMBL4553962 | — | — | 1 | - |
| CHEMBL4533741 | — | — | 1 | - |
| CHEMBL4580593 | — | — | 1 | - |
| CHEMBL4436659 | — | — | 1 | - |
| CHEMBL4448491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4518946 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4449047 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL4447804 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL4436797 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL4466265 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4561242 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL4579923 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL4521647 | — | pIC50 | - | — | - | |
| CHEMBL4545906 | — | pIC50 | - | — | - | |
| CHEMBL4553962 | — | pIC50 | - | — | - | |
| CHEMBL4533741 | — | pIC50 | - | — | - | |
| CHEMBL4580593 | — | pIC50 | - | — | - | |
| CHEMBL4436659 | — | pIC50 | - | — | - | |
| CHEMBL4448491 | — | pIC50 | - | — | - |