Assay Detail
ADMET
CHEMBL4326154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prostaglandin E2 from recombinant human full length EP4 receptor expressed in Chem-1 cell membranes after 60 mins by liquid scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.78 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 8.30 |
| CHEMBL3707245 | OMIDENEPAG | 2.0 | 1 | 5.26 |
| CHEMBL4297666 | OMIDENEPAG ISOPROPYL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3707245 | OMIDENEPAG | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL4297666 | OMIDENEPAG ISOPROPYL | IC50 | > | 10000.0 | nM | - |