Compound Detail
CHEMBL4297666
OMIDENEPAG ISOPROPYL 💊 Approved Drug
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💊 Approved Drug
CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1
Basic Information
| ChEMBL ID | CHEMBL4297666 |
| Name | OMIDENEPAG ISOPROPYL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | VIQCWEGEHRBLAC-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL3707245 |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
7
Publications
3
Known Names
3
Indications
1
Mechanisms
Molecular Properties
520.6
MW (Da)
3.42
ALogP
9
HBA
1
HBD
119.3
PSA (Ų)
0.30
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2022 |
| Availability | Discontinued |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Prostanoid EP2 receptor agonist | AGONIST | Prostaglandin E2 receptor EP2 subtype | ✓ | ✓ |
Indications
Glaucoma, Open-Angle Ocular Hypertension Glaucoma
Activity Summary
EC50 1 meas. best 8.96
IC50 1 meas. best 5.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP2 subtype CHEMBL1881 | EC50 | 8.96 | 8.96 | 1.1 | 1 |
| Prostaglandin E2 receptor EP2 subtype CHEMBL1881 | IC50 | 5.38 | 5.38 | 4180.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP2 subtype | EC50 | = | 1.1 | nM | 8.96 | Agonist activity at human EP2 receptor expressed in HEK293 cells | 39137454 |
| Prostaglandin E2 receptor EP2 subtype | IC50 | = | 4180.0 | nM | 5.38 | Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293... | 29995405 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29995405 | 10.1021/acs.jmedchem.8b00808 | Cynomolgus monkey | 2 |
| 29995405 | 10.1021/acs.jmedchem.8b00808 | Prostaglandin E2 receptor EP2 subtype | 1 |
| 29995405 | 10.1021/acs.jmedchem.8b00808 | Prostaglandin E2 receptor EP1 subtype | 1 |
| 29995405 | 10.1021/acs.jmedchem.8b00808 | Prostaglandin E2 receptor EP3 subtype | 1 |
| 29995405 | 10.1021/acs.jmedchem.8b00808 | Prostaglandin E2 receptor EP4 subtype | 1 |
| 29995405 | 10.1021/acs.jmedchem.8b00808 | No relevant target | 1 |
| 39137454 | 10.1016/j.ejmech.2024.116759 | Prostaglandin E2 receptor EP2 subtype | 1 |
Data from ChEMBL 36 via Core Engine