Assay Detail
Binding
CHEMBL4326753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DOT1L (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase, H3 lysine-79 specific (CHEMBL1795117) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Quinoline and quinolone dimers and their biological activities: An overview.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.56 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4515319 | — | — | 1 | 5.97 |
| CHEMBL2297965 | — | — | 1 | 5.97 |
| CHEMBL4541986 | — | — | 1 | 5.82 |
| CHEMBL4459321 | — | — | 1 | 5.36 |
| CHEMBL4452304 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4515319 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL2297965 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4541986 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4459321 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL4452304 | — | IC50 | = | 21670.0 | nM | 4.66 |