Assay Detail
Binding
CHEMBL4326985
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Binding affinity to human partial length JNK3 (V28 to Q422 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 6.15 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7064 | — | — | 1 | 7.66 |
| CHEMBL4582239 | — | — | 1 | 7.12 |
| CHEMBL3759098 | — | — | 1 | 7.00 |
| CHEMBL1098827 | — | — | 1 | 6.56 |
| CHEMBL4514173 | — | — | 1 | 6.55 |
| CHEMBL4536915 | — | — | 1 | 6.51 |
| CHEMBL4521282 | — | — | 1 | 6.47 |
| CHEMBL4593099 | — | — | 1 | 6.41 |
| CHEMBL4583031 | — | — | 1 | 6.15 |
| CHEMBL4524938 | — | — | 1 | 6.04 |
| CHEMBL4449918 | — | — | 1 | 5.89 |
| CHEMBL4457644 | — | — | 1 | 5.54 |
| CHEMBL4553054 | — | — | 1 | 5.41 |
| CHEMBL4474210 | — | — | 1 | 5.37 |
| CHEMBL4439862 | — | — | 1 | 5.22 |
| CHEMBL4541080 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7064 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL4582239 | — | Kd | = | 76.0 | nM | 7.12 |
| CHEMBL3759098 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL1098827 | — | Kd | = | 275.0 | nM | 6.56 |
| CHEMBL4514173 | — | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL4536915 | — | Kd | = | 310.0 | nM | 6.51 |
| CHEMBL4521282 | — | Kd | = | 340.0 | nM | 6.47 |
| CHEMBL4593099 | — | Kd | = | 390.0 | nM | 6.41 |
| CHEMBL4583031 | — | Kd | = | 710.0 | nM | 6.15 |
| CHEMBL4524938 | — | Kd | = | 910.0 | nM | 6.04 |
| CHEMBL4449918 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL4457644 | — | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL4553054 | — | Kd | = | 3900.0 | nM | 5.41 |
| CHEMBL4474210 | — | Kd | = | 4300.0 | nM | 5.37 |
| CHEMBL4439862 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL4541080 | — | Kd | = | 28500.0 | nM | 4.54 |