Assay Detail
Binding
CHEMBL4327281
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC4 using Boc-Lys(trifluoroacetyl)-AMC as substrate by homogeneous fluorescence release assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of novel quinazoline derivatives as potent antiplasmodial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.62 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3110004 | — | — | 1 | 6.52 |
| CHEMBL4550522 | — | — | 1 | 5.57 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 5.42 |
| CHEMBL4435005 | — | — | 1 | 4.96 |
| CHEMBL4593437 | — | — | 1 | - |
| CHEMBL4476057 | — | — | 1 | - |
| CHEMBL4469596 | — | — | 1 | - |
| CHEMBL4521590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3110004 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4550522 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4435005 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4593437 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4476057 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4469596 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4521590 | — | IC50 | > | 50000.0 | nM | - |