Assay Detail
Binding
CHEMBL4327418
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Inhibition of ZIKV 2'-O-MTase assessed as reduction in [3H]AdoMet transfer on to capped GpppAC4 RNA after 30 mins by microbeta liquid scintillation counting method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zika virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.34 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4556728 | — | — | 1 | 4.72 |
| CHEMBL3899268 | — | — | 1 | 4.62 |
| CHEMBL4446745 | — | — | 1 | 4.55 |
| CHEMBL3971531 | — | — | 1 | 4.51 |
| CHEMBL3959384 | — | — | 1 | 4.48 |
| CHEMBL4465538 | — | — | 1 | 4.21 |
| CHEMBL3941938 | — | — | 1 | 4.17 |
| CHEMBL4454666 | — | — | 1 | 4.08 |
| CHEMBL3976785 | — | — | 1 | 4.06 |
| CHEMBL4522746 | — | — | 1 | 4.02 |
| CHEMBL4475329 | — | — | 1 | - |
| CHEMBL4551201 | — | — | 1 | - |
| CHEMBL4578774 | — | — | 1 | - |
| CHEMBL4538799 | — | — | 1 | - |
| CHEMBL4449695 | — | — | 1 | - |
| CHEMBL4436568 | — | — | 1 | - |
| CHEMBL4437452 | — | — | 1 | - |
| CHEMBL4522025 | — | — | 1 | - |
| CHEMBL4436970 | — | — | 1 | - |
| CHEMBL4513879 | — | — | 1 | - |
| CHEMBL3890313 | — | — | 1 | - |
| CHEMBL4547767 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4556728 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3899268 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4446745 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3971531 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3959384 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4465538 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL3941938 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL4454666 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL3976785 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL4522746 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL4475329 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL4551201 | — | IC50 | - | — | - | |
| CHEMBL4578774 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL4538799 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL4449695 | — | IC50 | - | — | - | |
| CHEMBL4436568 | — | IC50 | = | 135000.0 | nM | - |
| CHEMBL4437452 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL4522025 | — | IC50 | = | 185000.0 | nM | - |
| CHEMBL4436970 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL4513879 | — | IC50 | = | 111000.0 | nM | - |
| CHEMBL3890313 | — | IC50 | = | 221000.0 | nM | - |
| CHEMBL4547767 | — | IC50 | = | 132000.0 | nM | - |