Assay Detail
Binding
CHEMBL4327419
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Inhibition of WNV 2'-O-MTase assessed as reduction in [3H]AdoMet transfer on to capped GpppAC4 RNA after 30 mins by microbeta liquid scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | West Nile virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.29 | 4.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3890313 | — | — | 1 | 4.29 |
| CHEMBL3959384 | — | — | 1 | 4.29 |
| CHEMBL3899268 | — | — | 1 | 4.29 |
| CHEMBL3976785 | — | — | 1 | 4.29 |
| CHEMBL3971531 | — | — | 1 | 4.29 |
| CHEMBL3941938 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3890313 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3959384 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3899268 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3976785 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3971531 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3941938 | — | IC50 | = | 51000.0 | nM | 4.29 |