Assay Detail
Binding
CHEMBL4329316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured at 1 min time interval for 10 mins by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multitarget-directed ligands targeting acetylcholinesterase and σ<sub>1</sub> receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.11 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.22 |
| CHEMBL4585990 | — | — | 1 | 7.88 |
| CHEMBL4526050 | — | — | 1 | 7.69 |
| CHEMBL4444843 | — | — | 1 | 7.54 |
| CHEMBL4454706 | — | — | 1 | 7.40 |
| CHEMBL4529710 | — | — | 1 | 7.29 |
| CHEMBL4559904 | — | — | 1 | 7.07 |
| CHEMBL4537101 | — | — | 1 | 7.04 |
| CHEMBL4562793 | — | — | 1 | 7.03 |
| CHEMBL4578844 | — | — | 1 | 6.88 |
| CHEMBL4541090 | — | — | 1 | 6.58 |
| CHEMBL4540355 | — | — | 1 | 6.56 |
| CHEMBL4583738 | — | — | 1 | 6.25 |
| CHEMBL4567394 | — | — | 1 | 6.14 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
| CHEMBL85251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4585990 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL4526050 | — | IC50 | = | 20.4 | nM | 7.69 |
| CHEMBL4444843 | — | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL4454706 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4529710 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4559904 | — | IC50 | = | 84.4 | nM | 7.07 |
| CHEMBL4537101 | — | IC50 | = | 91.4 | nM | 7.04 |
| CHEMBL4562793 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4578844 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4541090 | — | IC50 | = | 260.6 | nM | 6.58 |
| CHEMBL4540355 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL4583738 | — | IC50 | = | 559.0 | nM | 6.25 |
| CHEMBL4567394 | — | IC50 | = | 716.0 | nM | 6.14 |
| CHEMBL54 | HALOPERIDOL | IC50 | - | — | - | |
| CHEMBL85251 | — | IC50 | - | — | - |