Assay Detail
Binding
CHEMBL4329323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by CCK-8 assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Weiss/1943(H1N1)) |
| Cell Type | MDCK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polymerase basic protein 2 (CHEMBL3317339) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) |
Publication
Design, synthesis and biological evaluation of novel, orally bioavailable pyrimidine-fused heterocycles as influenza PB2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 8.11 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4593027 | — | — | 1 | 10.22 |
| CHEMBL4472219 | — | — | 1 | 9.70 |
| CHEMBL4568323 | — | — | 1 | 9.70 |
| CHEMBL4570851 | — | — | 1 | 9.40 |
| CHEMBL4434862 | — | — | 1 | 9.30 |
| CHEMBL4466462 | — | — | 1 | 9.30 |
| CHEMBL3318007 | PIMODIVIR | 3.0 | 1 | 9.22 |
| CHEMBL4547565 | — | — | 1 | 8.85 |
| CHEMBL4469158 | — | — | 1 | 8.59 |
| CHEMBL4470294 | — | — | 1 | 8.55 |
| CHEMBL4435833 | — | — | 1 | 8.52 |
| CHEMBL4444973 | — | — | 1 | 8.40 |
| CHEMBL4529778 | — | — | 1 | 8.35 |
| CHEMBL4468219 | — | — | 1 | 8.28 |
| CHEMBL4469921 | — | — | 1 | 8.26 |
| CHEMBL4459959 | — | — | 1 | 8.02 |
| CHEMBL4524775 | — | — | 1 | 8.00 |
| CHEMBL4567115 | — | — | 1 | 8.00 |
| CHEMBL4530239 | — | — | 1 | 7.96 |
| CHEMBL4522400 | — | — | 1 | 7.96 |
| CHEMBL4527175 | — | — | 1 | 7.92 |
| CHEMBL4562249 | — | — | 1 | 7.92 |
| CHEMBL4567152 | — | — | 1 | 7.89 |
| CHEMBL4514982 | — | — | 1 | 7.85 |
| CHEMBL4464813 | — | — | 1 | 7.70 |
| CHEMBL4542293 | — | — | 1 | 7.62 |
| CHEMBL4580408 | — | — | 1 | 7.16 |
| CHEMBL4538856 | — | — | 1 | 6.96 |
| CHEMBL4589525 | — | — | 1 | 6.72 |
| CHEMBL4513835 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4593027 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL4472219 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4568323 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4570851 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4434862 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4466462 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3318007 | PIMODIVIR | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4547565 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4469158 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4470294 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4435833 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4444973 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4529778 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4468219 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4469921 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4459959 | — | EC50 | = | 9.6 | nM | 8.02 |
| CHEMBL4524775 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4567115 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4530239 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4522400 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4527175 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4562249 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4567152 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4514982 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4464813 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4542293 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4580408 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4538856 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4589525 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4513835 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4453678 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4548835 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4519832 | — | EC50 | = | 2000.0 | nM | 5.70 |