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Assay Detail

CHEMBL4329375

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Functional
Antiproliferative activity against human Kasumi-1 cells after 72 hrs by resazurin dye-based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Kasumi 1
Confidence 1 — Organism
Curated By Autocuration

Target

Kasumi 1 (CHEMBL613988)
Type CELL-LINE
Organism Homo sapiens

Publication

Highly fluorescent and HDAC6 selective scriptaid analogues.
Fleming CL, Natoli A, Schreuders J, Devlin M, Yoganantharajah P, Gibert Y, Leslie KG, New EJ, Ashton TD, Pfeffer FM.
Eur J Med Chem (2019) 162 : 321 -333
PubMed 30448419 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.38 7.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4475116 1 7.02
CHEMBL4526647 1 6.55
CHEMBL4160632 1 6.54
CHEMBL4461622 1 6.50
CHEMBL4532304 1 6.44
CHEMBL96051 SCRIPTAID 1 6.31
CHEMBL4465218 1 6.24
CHEMBL4476425 1 6.19
CHEMBL4567832 1 6.09
CHEMBL330201 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4475116 IC50 = 96.0 nM 7.02
CHEMBL4526647 IC50 = 280.0 nM 6.55
CHEMBL4160632 IC50 = 290.0 nM 6.54
CHEMBL4461622 IC50 = 320.0 nM 6.50
CHEMBL4532304 IC50 = 360.0 nM 6.44
CHEMBL96051 SCRIPTAID IC50 = 490.0 nM 6.31
CHEMBL4465218 IC50 = 570.0 nM 6.24
CHEMBL4476425 IC50 = 640.0 nM 6.19
CHEMBL4567832 IC50 = 810.0 nM 6.09
CHEMBL330201 IC50 = 1090.0 nM 5.96