Assay Detail
Binding
CHEMBL4330036
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Inhibition of ABHD16A (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.08 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564841 | — | — | 1 | 7.50 |
| CHEMBL4525638 | — | — | 1 | 7.05 |
| CHEMBL1673415 | PALMOSTATIN B | — | 1 | 7.00 |
| CHEMBL175247 | ORLISTAT | 4.0 | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564841 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4525638 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1673415 | PALMOSTATIN B | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL175247 | ORLISTAT | IC50 | = | 170.0 | nM | 6.77 |