Assay Detail
Binding
CHEMBL4330041
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Reversible inhibition of human ABHD16A expressed in HEK293 cells preincubated for 30 mins followed by 40 fold compound dilution and subsequent 1-LG substrate addition and measured at 30 mins time interval for 120 mins by fluorometric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.38 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1673415 | PALMOSTATIN B | — | 1 | 7.24 |
| CHEMBL4591378 | — | — | 1 | 4.50 |
| CHEMBL4585683 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1673415 | PALMOSTATIN B | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4591378 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL4585683 | — | IC50 | = | 41100.0 | nM | 4.39 |