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Assay Detail

CHEMBL4330232

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Hepatitis C virus genotype 2a infected in human Huh-luc replicon cells after 3 days by luciferase assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides.
Tokarenko A, Lišková B, Smoleń S, Táborská N, Tichý M, Gurská S, Perlíková P, Frydrych I, Tloušt'ová E, Znojek P, Mertlíková-Kaiserová H, Poštová Slavětínská L, Pohl R, Klepetářová B, Khalid NU, Wenren Y, Laposa RR, Džubák P, Hajdúch M, Hocek M.
J Med Chem (2018) 61 : 9347 -9359
PubMed 30281308 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 27 6.04 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4532596 1 7.22
CHEMBL4467186 1 6.92
CHEMBL4567695 1 6.89
CHEMBL4556165 1 6.66
CHEMBL4591383 1 6.62
CHEMBL4585910 1 6.62
CHEMBL4450152 1 6.55
CHEMBL4483740 1 6.54
CHEMBL4447775 1 6.48
CHEMBL4576288 1 6.11
CHEMBL562967 MERICITABINE 2.0 1 6.00
CHEMBL4585392 1 5.46
CHEMBL4554008 1 4.81
CHEMBL4476539 1 4.77
CHEMBL4470770 1 4.49
CHEMBL4517245 1 4.47
CHEMBL4454930 1 -
CHEMBL4462448 1 -
CHEMBL4462344 1 -
CHEMBL4543054 1 -
CHEMBL4455893 1 -
CHEMBL4589727 1 -
CHEMBL4438098 1 -
CHEMBL4458110 1 -
CHEMBL4556038 1 -
CHEMBL4589668 1 -
CHEMBL4580524 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4532596 EC50 = 60.0 nM 7.22
CHEMBL4467186 EC50 = 120.0 nM 6.92
CHEMBL4567695 EC50 = 130.0 nM 6.89
CHEMBL4556165 EC50 = 220.0 nM 6.66
CHEMBL4591383 EC50 = 240.0 nM 6.62
CHEMBL4585910 EC50 = 240.0 nM 6.62
CHEMBL4450152 EC50 = 280.0 nM 6.55
CHEMBL4483740 EC50 = 290.0 nM 6.54
CHEMBL4447775 EC50 = 330.0 nM 6.48
CHEMBL4576288 EC50 = 770.0 nM 6.11
CHEMBL562967 MERICITABINE EC50 = 990.0 nM 6.00
CHEMBL4585392 EC50 = 3450.0 nM 5.46
CHEMBL4554008 EC50 = 15490.0 nM 4.81
CHEMBL4476539 EC50 = 17000.0 nM 4.77
CHEMBL4470770 EC50 = 32500.0 nM 4.49
CHEMBL4517245 EC50 = 33860.0 nM 4.47
CHEMBL4454930 EC50 > 44440.0 nM -
CHEMBL4462448 EC50 > 44440.0 nM -
CHEMBL4462344 EC50 > 44440.0 nM -
CHEMBL4543054 EC50 > 44440.0 nM -
CHEMBL4455893 EC50 > 44440.0 nM -
CHEMBL4589727 EC50 > 44440.0 nM -
CHEMBL4438098 EC50 > 44440.0 nM -
CHEMBL4458110 EC50 > 44440.0 nM -
CHEMBL4556038 EC50 > 44440.0 nM -
CHEMBL4589668 EC50 > 44440.0 nM -
CHEMBL4580524 EC50 > 44440.0 nM -