Assay Detail
ADMET
CHEMBL4330458
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Cytotoxicity against human FHC cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | FHC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N<sup>1</sup>-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)-N<sup>3</sup>-(2-(2,6-difluorophenyl)-4-oxothiazolidin-3-yl)urea as a multi-tyrosine kinase inhibitor for drug-sensitive and drug-resistant cancers treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.85 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472209 | — | — | 1 | 6.27 |
| CHEMBL4587222 | — | — | 1 | 5.93 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472209 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4587222 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 4400.0 | nM | 5.36 |