Assay Detail
Functional
CHEMBL4330510
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Antiproliferative activity against human EAhy926 cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EA.hy 926 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.52 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475290 | — | — | 1 | 8.37 |
| CHEMBL4473535 | — | — | 1 | 7.80 |
| CHEMBL4469871 | — | — | 1 | 7.75 |
| CHEMBL4464137 | — | — | 1 | 7.50 |
| CHEMBL4471330 | — | — | 1 | 7.49 |
| CHEMBL321336 | — | — | 1 | 7.45 |
| CHEMBL4547354 | — | — | 1 | 7.17 |
| CHEMBL4436712 | — | — | 1 | 7.11 |
| CHEMBL4586497 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475290 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4473535 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL4469871 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL4464137 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL4471330 | — | IC50 | = | 32.6 | nM | 7.49 |
| CHEMBL321336 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL4547354 | — | IC50 | = | 67.8 | nM | 7.17 |
| CHEMBL4436712 | — | IC50 | = | 78.6 | nM | 7.11 |
| CHEMBL4586497 | — | IC50 | = | 90.8 | nM | 7.04 |