Assay Detail
Binding
CHEMBL4331195
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Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptake
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of small molecule modulators targeting glutamine metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.16 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | 6.80 |
| CHEMBL1834956 | — | — | 1 | 4.52 |
| CHEMBL1834954 | — | — | 1 | 4.16 |
| CHEMBL1834960 | — | — | 1 | - |
| CHEMBL1834958 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1834956 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1834954 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1834960 | — | IC50 | = | 920000.0 | nM | - |
| CHEMBL1834958 | — | IC50 | = | 700000.0 | nM | - |