Assay Detail
Binding
CHEMBL4331196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cystine/glutamate antiporter system xc- in human HT1080 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ free uptake buffer by scintillation counting assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of small molecule modulators targeting glutamine metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.70 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401989 | ERASTIN | — | 1 | 6.70 |
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401989 | ERASTIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL421 | SULFASALAZINE | IC50 | = | 450000.0 | nM | - |