Assay Detail
Functional
CHEMBL4331380
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.68 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4584494 | — | — | 1 | 8.70 |
| CHEMBL498271 | — | — | 1 | 8.70 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.66 |
| CHEMBL4517935 | — | — | 1 | 8.47 |
| CHEMBL4551060 | — | — | 1 | 8.42 |
| CHEMBL4474171 | — | — | 1 | 8.24 |
| CHEMBL4573850 | — | — | 1 | 8.07 |
| CHEMBL4570016 | — | — | 1 | 7.96 |
| CHEMBL4538738 | — | — | 1 | 7.92 |
| CHEMBL4445657 | — | — | 1 | 7.82 |
| CHEMBL4574710 | — | — | 1 | 7.72 |
| CHEMBL4565057 | — | — | 1 | 7.70 |
| CHEMBL4464329 | — | — | 1 | 7.64 |
| CHEMBL4516996 | — | — | 1 | 7.62 |
| CHEMBL4476716 | — | — | 1 | 7.40 |
| CHEMBL4568448 | — | — | 1 | 6.71 |
| CHEMBL4591900 | — | — | 1 | 6.52 |
| CHEMBL4580553 | — | — | 1 | 6.40 |
| CHEMBL4529564 | — | — | 1 | 5.30 |
| CHEMBL4572347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4584494 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL498271 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4517935 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4551060 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4474171 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4573850 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4570016 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4538738 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4445657 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4574710 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4565057 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4464329 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4516996 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL4476716 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4568448 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4591900 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4580553 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4529564 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4572347 | — | IC50 | > | 10000.0 | nM | - |