Assay Detail
Functional
CHEMBL4331383
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Antiproliferative activity against human U87MG cells after 72 hrs by MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.19 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4584494 | — | — | 1 | 8.72 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.40 |
| CHEMBL4517935 | — | — | 1 | 8.26 |
| CHEMBL498271 | — | — | 1 | 8.09 |
| CHEMBL4551060 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4584494 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4517935 | — | IC50 | = | 5.49 | nM | 8.26 |
| CHEMBL498271 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4551060 | — | IC50 | = | 31.6 | nM | 7.50 |