Assay Detail
Functional
CHEMBL4331491
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Antiproliferative activity against human A375 cells after 72 hrs by Cell-Titer Glo assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.51 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577124 | LY-3009120 | 1.0 | 1 | 6.52 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 6.16 |
| CHEMBL4436132 | — | — | 1 | 5.70 |
| CHEMBL4586402 | — | — | 1 | 5.44 |
| CHEMBL4473290 | — | — | 1 | 5.37 |
| CHEMBL4555839 | — | — | 1 | 5.27 |
| CHEMBL4439157 | — | — | 1 | 5.19 |
| CHEMBL4438236 | — | — | 1 | 5.07 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577124 | LY-3009120 | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4436132 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4586402 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4473290 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4555839 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4439157 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4438236 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 13600.0 | nM | 4.87 |