Assay Detail
Binding
CHEMBL4331497
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ARaf (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase A-Raf (CHEMBL1169596) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.09 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577124 | LY-3009120 | 1.0 | 1 | 8.92 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 8.68 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 8.15 |
| CHEMBL4438236 | — | — | 1 | 8.07 |
| CHEMBL4436132 | — | — | 1 | 7.45 |
| CHEMBL4586402 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577124 | LY-3009120 | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4438236 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4436132 | — | IC50 | = | 35.7 | nM | 7.45 |
| CHEMBL4586402 | — | IC50 | = | 52.4 | nM | 7.28 |