Assay Detail
Binding
CHEMBL4331500
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of desthiobiotin-ATP acylphosphate probe binding to A-Raf in human A375 cells by MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase A-Raf (CHEMBL1169596) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.62 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577124 | LY-3009120 | 1.0 | 1 | 7.36 |
| CHEMBL4436132 | — | — | 1 | 6.56 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577124 | LY-3009120 | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4436132 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 1130.0 | nM | 5.95 |