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Assay Detail

CHEMBL4331534

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MV4-11 cells after 72 hrs by CellTiter Glo luminescent assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors.
Xing J, Zhang R, Jiang X, Hu T, Wang X, Qiao G, Wang J, Yang F, Luo X, Chen K, Shen J, Luo C, Jiang H, Zheng M.
Eur J Med Chem (2019) 163 : 281 -294
PubMed 30529546 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.28 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4518465 1 6.00
CHEMBL2094437 1 6.00
CHEMBL4567741 1 6.00
CHEMBL4448093 1 5.82
CHEMBL4563906 1 5.80
CHEMBL4469389 1 5.66
CHEMBL4514822 1 5.54
CHEMBL4470331 1 5.54
CHEMBL1454910 NITROXOLINE 4.0 1 5.31
CHEMBL4543026 1 5.28
CHEMBL4467977 1 5.05
CHEMBL4443068 1 5.05
CHEMBL4440666 1 5.02
CHEMBL4582810 1 4.94
CHEMBL4514104 1 4.90
CHEMBL4548295 1 4.69
CHEMBL4590925 1 4.65
CHEMBL1361699 1 4.57
CHEMBL4553865 1 4.54
CHEMBL4549696 1 -
CHEMBL4459745 1 -
CHEMBL4458650 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4518465 IC50 = 1000.0 nM 6.00
CHEMBL2094437 IC50 = 1000.0 nM 6.00
CHEMBL4567741 IC50 = 1000.0 nM 6.00
CHEMBL4448093 IC50 = 1500.0 nM 5.82
CHEMBL4563906 IC50 = 1600.0 nM 5.80
CHEMBL4469389 IC50 = 2200.0 nM 5.66
CHEMBL4514822 IC50 = 2900.0 nM 5.54
CHEMBL4470331 IC50 = 2900.0 nM 5.54
CHEMBL1454910 NITROXOLINE IC50 = 4900.0 nM 5.31
CHEMBL4543026 IC50 = 5200.0 nM 5.28
CHEMBL4467977 IC50 = 9000.0 nM 5.05
CHEMBL4443068 IC50 = 8900.0 nM 5.05
CHEMBL4440666 IC50 = 9600.0 nM 5.02
CHEMBL4582810 IC50 = 11500.0 nM 4.94
CHEMBL4514104 IC50 = 12700.0 nM 4.90
CHEMBL4548295 IC50 = 20400.0 nM 4.69
CHEMBL4590925 IC50 = 22400.0 nM 4.65
CHEMBL1361699 IC50 = 27000.0 nM 4.57
CHEMBL4553865 IC50 = 28500.0 nM 4.54
CHEMBL4549696 IC50 - -
CHEMBL4459745 IC50 - -
CHEMBL4458650 IC50 - -