Compound Detail
CHEMBL2094437
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Basic Information
| ChEMBL ID | CHEMBL2094437 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NATLUQYUVYCKGK-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
1
PK Parameters
8
Publications
0
Known Names
Molecular Properties
275.3
MW (Da)
3.34
ALogP
4
HBA
1
HBD
50.9
PSA (Ų)
0.61
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 CHEMBL1163125 | IC50 | 6.47 | 6.47 | 337.0 | 1 |
| MV4-11 CHEMBL613835 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 5.81 | 5.81 | 1550.0 | 1 |
| MM1.S CHEMBL4296471 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
| MDA-MB-231 CHEMBL400 | IC50 | 5.33 | 5.33 | 4700.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.5167 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | IC50 | = | 337.0 | nM | 6.47 | Inhibition of BRD4 BD1 (unknown origin) using biotin labelled NeC: SGRG-K(Ac)-GG... | 30529546 |
| MV4-11 | IC50 | = | 1000.0 | nM | 6.0 | Antiproliferative activity against human MV4-11 cells after 72 hrs by CellTiter ... | 30529546 |
| Trypanosoma brucei brucei | IC50 | = | 1550.0 | nM | 5.81 | DNDI: Inhibition of Human African Trypanosomiasis (HAT), STIB 795, in vitro | - |
| MM1.S | IC50 | = | 3000.0 | nM | 5.52 | Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter Gl... | 30529546 |
| MDA-MB-231 | IC50 | = | 4700.0 | nM | 5.33 | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTi... | 30529546 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30529546 | 10.1016/j.ejmech.2018.11.018 | Bromodomain-containing protein 4 | 4 |
| - | 10.6019/CHEMBL2094269 | Trypanosoma brucei brucei | 1 |
| - | 10.6019/CHEMBL2094269 | MRC5 | 1 |
| 30529546 | 10.1016/j.ejmech.2018.11.018 | MV4-11 | 1 |
| 30529546 | 10.1016/j.ejmech.2018.11.018 | MDA-MB-231 | 1 |
| 30529546 | 10.1016/j.ejmech.2018.11.018 | MM1.S | 1 |
| 30529546 | 10.1016/j.ejmech.2018.11.018 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 30529546 | 10.1016/j.ejmech.2018.11.018 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine