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Assay Detail

CHEMBL4331536

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Functional
Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter Glo luminescent assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MM1.S
Confidence 1 — Organism
Curated By Autocuration

Target

MM1.S (CHEMBL4296471)
Type CELL-LINE
Organism Homo sapiens

Publication

Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors.
Xing J, Zhang R, Jiang X, Hu T, Wang X, Qiao G, Wang J, Yang F, Luo X, Chen K, Shen J, Luo C, Jiang H, Zheng M.
Eur J Med Chem (2019) 163 : 281 -294
PubMed 30529546 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.73 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4567741 1 6.52
CHEMBL4563906 1 6.16
CHEMBL4514822 1 5.96
CHEMBL4470331 1 5.96
CHEMBL4469389 1 5.92
CHEMBL4582810 1 5.75
CHEMBL4448093 1 5.68
CHEMBL4467977 1 5.54
CHEMBL2094437 1 5.52
CHEMBL4443068 1 5.44
CHEMBL4543026 1 5.37
CHEMBL4518465 1 4.96
CHEMBL4549696 1 -
CHEMBL4459745 1 -
CHEMBL4553865 1 -
CHEMBL4458650 1 -
CHEMBL1361699 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4567741 IC50 = 300.0 nM 6.52
CHEMBL4563906 IC50 = 700.0 nM 6.16
CHEMBL4514822 IC50 = 1100.0 nM 5.96
CHEMBL4470331 IC50 = 1100.0 nM 5.96
CHEMBL4469389 IC50 = 1200.0 nM 5.92
CHEMBL4582810 IC50 = 1800.0 nM 5.75
CHEMBL4448093 IC50 = 2100.0 nM 5.68
CHEMBL4467977 IC50 = 2900.0 nM 5.54
CHEMBL2094437 IC50 = 3000.0 nM 5.52
CHEMBL4443068 IC50 = 3600.0 nM 5.44
CHEMBL4543026 IC50 = 4300.0 nM 5.37
CHEMBL4518465 IC50 = 10900.0 nM 4.96
CHEMBL4549696 IC50 - -
CHEMBL4459745 IC50 - -
CHEMBL4553865 IC50 - -
CHEMBL4458650 IC50 - -
CHEMBL1361699 IC50 - -