Assay Detail
Functional
CHEMBL4331535
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo luminescent assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.27 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4518465 | — | — | 1 | 5.96 |
| CHEMBL4567741 | — | — | 1 | 5.89 |
| CHEMBL4470331 | — | — | 1 | 5.66 |
| CHEMBL4514822 | — | — | 1 | 5.57 |
| CHEMBL4563906 | — | — | 1 | 5.44 |
| CHEMBL4448093 | — | — | 1 | 5.43 |
| CHEMBL2094437 | — | — | 1 | 5.33 |
| CHEMBL4543026 | — | — | 1 | 5.17 |
| CHEMBL4443068 | — | — | 1 | 4.91 |
| CHEMBL4467977 | — | — | 1 | 4.91 |
| CHEMBL4582810 | — | — | 1 | 4.50 |
| CHEMBL4469389 | — | — | 1 | 4.46 |
| CHEMBL4549696 | — | — | 1 | - |
| CHEMBL4459745 | — | — | 1 | - |
| CHEMBL4553865 | — | — | 1 | - |
| CHEMBL4458650 | — | — | 1 | - |
| CHEMBL1361699 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4518465 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4567741 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4470331 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4514822 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4563906 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4448093 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2094437 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4543026 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4443068 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4467977 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4582810 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL4469389 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL4549696 | — | IC50 | - | — | - | |
| CHEMBL4459745 | — | IC50 | - | — | - | |
| CHEMBL4553865 | — | IC50 | - | — | - | |
| CHEMBL4458650 | — | IC50 | - | — | - | |
| CHEMBL1361699 | — | IC50 | - | — | - |