Assay Detail
Binding
CHEMBL4331756
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Inhibition of PIM2 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the immunity protein kinases for immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.49 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3651966 | LGH-447 | 1.0 | 1 | 10.74 |
| CHEMBL2048872 | — | — | 1 | 8.30 |
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3651966 | LGH-447 | IC50 | = | 0.018 | nM | 10.74 |
| CHEMBL2048872 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1952329 | SGI-1776 | IC50 | = | 363.0 | nM | 6.44 |