Assay Detail
Functional
CHEMBL4332359
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Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M mutant after 72 hrs by CCK8 assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors and their anticancer activities - Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.56 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4468146 | — | — | 1 | 8.80 |
| CHEMBL4577402 | — | — | 1 | 8.21 |
| CHEMBL4456300 | — | — | 1 | 8.14 |
| CHEMBL4591414 | — | — | 1 | 8.13 |
| CHEMBL4441788 | — | — | 1 | 8.09 |
| CHEMBL4592101 | — | — | 1 | 7.97 |
| CHEMBL4473875 | — | — | 1 | 7.91 |
| CHEMBL4556389 | — | — | 1 | 7.86 |
| CHEMBL4557964 | — | — | 1 | 7.74 |
| CHEMBL4549345 | — | — | 1 | 7.56 |
| CHEMBL4577968 | — | — | 1 | 7.45 |
| CHEMBL4474073 | — | — | 1 | 7.44 |
| CHEMBL4589070 | — | — | 1 | 7.43 |
| CHEMBL4560518 | — | — | 1 | 7.40 |
| CHEMBL4450824 | — | — | 1 | 7.38 |
| CHEMBL4473690 | — | — | 1 | 7.31 |
| CHEMBL4447976 | — | — | 1 | 7.30 |
| CHEMBL4577883 | — | — | 1 | 7.30 |
| CHEMBL4457295 | — | — | 1 | 7.29 |
| CHEMBL4456662 | — | — | 1 | 7.18 |
| CHEMBL4443188 | — | — | 1 | 7.18 |
| CHEMBL4442324 | — | — | 1 | 7.14 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.02 |
| CHEMBL4465139 | — | — | 1 | 6.97 |
| CHEMBL4591886 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4468146 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4577402 | — | IC50 | = | 6.17 | nM | 8.21 |
| CHEMBL4456300 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4591414 | — | IC50 | = | 7.43 | nM | 8.13 |
| CHEMBL4441788 | — | IC50 | = | 8.21 | nM | 8.09 |
| CHEMBL4592101 | — | IC50 | = | 10.63 | nM | 7.97 |
| CHEMBL4473875 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL4556389 | — | IC50 | = | 13.72 | nM | 7.86 |
| CHEMBL4557964 | — | IC50 | = | 18.37 | nM | 7.74 |
| CHEMBL4549345 | — | IC50 | = | 27.56 | nM | 7.56 |
| CHEMBL4577968 | — | IC50 | = | 35.23 | nM | 7.45 |
| CHEMBL4474073 | — | IC50 | = | 36.09 | nM | 7.44 |
| CHEMBL4589070 | — | IC50 | = | 37.11 | nM | 7.43 |
| CHEMBL4560518 | — | IC50 | = | 39.44 | nM | 7.40 |
| CHEMBL4450824 | — | IC50 | = | 41.73 | nM | 7.38 |
| CHEMBL4473690 | — | IC50 | = | 49.31 | nM | 7.31 |
| CHEMBL4447976 | — | IC50 | = | 49.66 | nM | 7.30 |
| CHEMBL4577883 | — | IC50 | = | 49.92 | nM | 7.30 |
| CHEMBL4457295 | — | IC50 | = | 51.81 | nM | 7.29 |
| CHEMBL4456662 | — | IC50 | = | 65.6 | nM | 7.18 |
| CHEMBL4443188 | — | IC50 | = | 66.5 | nM | 7.18 |
| CHEMBL4442324 | — | IC50 | = | 72.49 | nM | 7.14 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 96.07 | nM | 7.02 |
| CHEMBL4465139 | — | IC50 | = | 106.8 | nM | 6.97 |
| CHEMBL4591886 | — | IC50 | = | 190.4 | nM | 6.72 |