Assay Detail
Functional
CHEMBL4332361
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A431 cells harboring wild-type EGFR after 72 hrs by CCK8 assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors and their anticancer activities - Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.52 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473875 | — | — | 1 | 8.82 |
| CHEMBL4556389 | — | — | 1 | 8.47 |
| CHEMBL4591886 | — | — | 1 | 8.26 |
| CHEMBL4450824 | — | — | 1 | 8.23 |
| CHEMBL4457295 | — | — | 1 | 8.22 |
| CHEMBL4456662 | — | — | 1 | 8.19 |
| CHEMBL4592101 | — | — | 1 | 8.09 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.99 |
| CHEMBL4473690 | — | — | 1 | 7.94 |
| CHEMBL4577402 | — | — | 1 | 7.86 |
| CHEMBL4443188 | — | — | 1 | 7.78 |
| CHEMBL4456300 | — | — | 1 | 7.70 |
| CHEMBL4474073 | — | — | 1 | 7.63 |
| CHEMBL4468146 | — | — | 1 | 7.62 |
| CHEMBL4577883 | — | — | 1 | 7.37 |
| CHEMBL4442324 | — | — | 1 | 7.26 |
| CHEMBL4465139 | — | — | 1 | 7.19 |
| CHEMBL4447976 | — | — | 1 | 7.10 |
| CHEMBL4557964 | — | — | 1 | 7.02 |
| CHEMBL4549345 | — | — | 1 | 6.83 |
| CHEMBL4577968 | — | — | 1 | 6.68 |
| CHEMBL4591414 | — | — | 1 | 6.54 |
| CHEMBL4441788 | — | — | 1 | 6.53 |
| CHEMBL4589070 | — | — | 1 | 6.43 |
| CHEMBL4560518 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473875 | — | IC50 | = | 1.52 | nM | 8.82 |
| CHEMBL4556389 | — | IC50 | = | 3.37 | nM | 8.47 |
| CHEMBL4591886 | — | IC50 | = | 5.45 | nM | 8.26 |
| CHEMBL4450824 | — | IC50 | = | 5.86 | nM | 8.23 |
| CHEMBL4457295 | — | IC50 | = | 6.01 | nM | 8.22 |
| CHEMBL4456662 | — | IC50 | = | 6.48 | nM | 8.19 |
| CHEMBL4592101 | — | IC50 | = | 8.15 | nM | 8.09 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 10.21 | nM | 7.99 |
| CHEMBL4473690 | — | IC50 | = | 11.45 | nM | 7.94 |
| CHEMBL4577402 | — | IC50 | = | 13.68 | nM | 7.86 |
| CHEMBL4443188 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL4456300 | — | IC50 | = | 20.06 | nM | 7.70 |
| CHEMBL4474073 | — | IC50 | = | 23.34 | nM | 7.63 |
| CHEMBL4468146 | — | IC50 | = | 24.02 | nM | 7.62 |
| CHEMBL4577883 | — | IC50 | = | 43.03 | nM | 7.37 |
| CHEMBL4442324 | — | IC50 | = | 54.45 | nM | 7.26 |
| CHEMBL4465139 | — | IC50 | = | 64.13 | nM | 7.19 |
| CHEMBL4447976 | — | IC50 | = | 79.49 | nM | 7.10 |
| CHEMBL4557964 | — | IC50 | = | 94.82 | nM | 7.02 |
| CHEMBL4549345 | — | IC50 | = | 148.2 | nM | 6.83 |
| CHEMBL4577968 | — | IC50 | = | 207.4 | nM | 6.68 |
| CHEMBL4591414 | — | IC50 | = | 289.1 | nM | 6.54 |
| CHEMBL4441788 | — | IC50 | = | 296.6 | nM | 6.53 |
| CHEMBL4589070 | — | IC50 | = | 368.9 | nM | 6.43 |
| CHEMBL4560518 | — | IC50 | = | 572.2 | nM | 6.24 |