Assay Detail
Functional
CHEMBL4332362
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Antiproliferative activity against human MDA-MB-453 cells after 72 hrs by CCK8 assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors and their anticancer activities - Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.19 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473875 | — | — | 1 | 9.21 |
| CHEMBL4557964 | — | — | 1 | 9.17 |
| CHEMBL4456300 | — | — | 1 | 8.78 |
| CHEMBL4577402 | — | — | 1 | 8.60 |
| CHEMBL4465139 | — | — | 1 | 8.59 |
| CHEMBL4473690 | — | — | 1 | 8.47 |
| CHEMBL4589070 | — | — | 1 | 8.43 |
| CHEMBL4441788 | — | — | 1 | 8.40 |
| CHEMBL4457295 | — | — | 1 | 8.25 |
| CHEMBL4456662 | — | — | 1 | 7.90 |
| CHEMBL4591414 | — | — | 1 | 7.83 |
| CHEMBL4560518 | — | — | 1 | 7.82 |
| CHEMBL4549345 | — | — | 1 | 7.74 |
| CHEMBL4577968 | — | — | 1 | 7.67 |
| CHEMBL4442324 | — | — | 1 | 7.24 |
| CHEMBL4556389 | — | — | 1 | 6.88 |
| CHEMBL4468146 | — | — | 1 | - |
| CHEMBL4591886 | — | — | 1 | - |
| CHEMBL4474073 | — | — | 1 | - |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | - |
| CHEMBL4447976 | — | — | 1 | - |
| CHEMBL4450824 | — | — | 1 | - |
| CHEMBL4592101 | — | — | 1 | - |
| CHEMBL4443188 | — | — | 1 | - |
| CHEMBL4577883 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473875 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL4557964 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL4456300 | — | IC50 | = | 1.65 | nM | 8.78 |
| CHEMBL4577402 | — | IC50 | = | 2.52 | nM | 8.60 |
| CHEMBL4465139 | — | IC50 | = | 2.55 | nM | 8.59 |
| CHEMBL4473690 | — | IC50 | = | 3.42 | nM | 8.47 |
| CHEMBL4589070 | — | IC50 | = | 3.71 | nM | 8.43 |
| CHEMBL4441788 | — | IC50 | = | 3.99 | nM | 8.40 |
| CHEMBL4457295 | — | IC50 | = | 5.67 | nM | 8.25 |
| CHEMBL4456662 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL4591414 | — | IC50 | = | 14.87 | nM | 7.83 |
| CHEMBL4560518 | — | IC50 | = | 15.05 | nM | 7.82 |
| CHEMBL4549345 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL4577968 | — | IC50 | = | 21.57 | nM | 7.67 |
| CHEMBL4442324 | — | IC50 | = | 58.2 | nM | 7.24 |
| CHEMBL4556389 | — | IC50 | = | 130.5 | nM | 6.88 |
| CHEMBL4468146 | — | IC50 | - | — | - | |
| CHEMBL4591886 | — | IC50 | - | — | - | |
| CHEMBL4474073 | — | IC50 | - | — | - | |
| CHEMBL1173655 | AFATINIB | IC50 | - | — | - | |
| CHEMBL4447976 | — | IC50 | - | — | - | |
| CHEMBL4450824 | — | IC50 | - | — | - | |
| CHEMBL4592101 | — | IC50 | - | — | - | |
| CHEMBL4443188 | — | IC50 | - | — | - | |
| CHEMBL4577883 | — | IC50 | - | — | - |