Assay Detail
Functional
CHEMBL4332382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RES056 containing reverse transcriptase K103N + Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.54 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2364608 | DORAVIRINE | 4.0 | 1 | 7.82 |
| CHEMBL4448359 | — | — | 1 | 6.71 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.61 |
| CHEMBL4467417 | — | — | 1 | 6.46 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 5.11 |
| CHEMBL4461473 | — | — | 1 | - |
| CHEMBL4577434 | — | — | 1 | - |
| CHEMBL4469538 | — | — | 1 | - |
| CHEMBL4579228 | — | — | 1 | - |
| CHEMBL4550743 | — | — | 1 | - |
| CHEMBL4582364 | — | — | 1 | - |
| CHEMBL4530139 | — | — | 1 | - |
| CHEMBL4434794 | — | — | 1 | - |
| CHEMBL4453611 | — | — | 1 | - |
| CHEMBL4576491 | — | — | 1 | - |
| CHEMBL4471313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2364608 | DORAVIRINE | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4448359 | — | EC50 | = | 196.0 | nM | 6.71 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 244.0 | nM | 6.61 |
| CHEMBL4467417 | — | EC50 | = | 343.0 | nM | 6.46 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL4461473 | — | EC50 | > | 234000.0 | nM | - |
| CHEMBL4577434 | — | EC50 | > | 231000.0 | nM | - |
| CHEMBL4469538 | — | EC50 | > | 41900.0 | nM | - |
| CHEMBL4579228 | — | EC50 | > | 133000.0 | nM | - |
| CHEMBL4550743 | — | EC50 | > | 111000.0 | nM | - |
| CHEMBL4582364 | — | EC50 | > | 183000.0 | nM | - |
| CHEMBL4530139 | — | EC50 | > | 254000.0 | nM | - |
| CHEMBL4434794 | — | EC50 | > | 82300.0 | nM | - |
| CHEMBL4453611 | — | EC50 | > | 269000.0 | nM | - |
| CHEMBL4576491 | — | EC50 | > | 87900.0 | nM | - |
| CHEMBL4471313 | — | EC50 | > | 112000.0 | nM | - |