Assay Detail
Binding
CHEMBL4332981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK3 in human CTLL2 cells assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 2 hrs followed by IL15 stimulation measured after 30 mins by Western blot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of an Orally Available Janus Kinase 3 Selective Covalent Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.42 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4450627 | — | — | 1 | 6.85 |
| CHEMBL1650951 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4450627 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL1650951 | — | EC50 | = | 1042.0 | nM | 5.98 |