Assay Detail
Binding
CHEMBL4333048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDK4 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (CHEMBL4141) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.57 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471264 | — | — | 1 | 7.08 |
| CHEMBL4439097 | — | — | 1 | 6.84 |
| CHEMBL4475200 | — | — | 1 | 6.22 |
| CHEMBL4082531 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471264 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4439097 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4475200 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4082531 | — | IC50 | = | 760.0 | nM | 6.12 |