Assay Detail
Binding
CHEMBL4334024
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Inhibition of yeast alpha-glucosidase pre-incubated for 10 mins followed by pNPG substrate addition and measured every 30 secs for 35 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of α-Glucosidase Inhibitors in Machilus litseifolia by Combined Use of High-Resolution α-Glucosidase Inhibition Profiling and HPLC-PDA-HRMS-SPE-NMR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.83 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4579556 | — | — | 1 | 5.23 |
| CHEMBL4579150 | — | — | 1 | 5.17 |
| CHEMBL4468168 | — | — | 1 | 5.00 |
| CHEMBL1642586 | — | — | 1 | 4.89 |
| CHEMBL4442596 | — | — | 1 | 4.79 |
| CHEMBL4456260 | — | — | 1 | 4.57 |
| CHEMBL4436077 | — | — | 1 | 4.55 |
| CHEMBL4580792 | — | — | 1 | 4.45 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4579556 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4579150 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4468168 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL1642586 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4442596 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4456260 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL4436077 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL4580792 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 266100.0 | nM | - |