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Compound Detail

CHEMBL4468168

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COc1ccc(-c2oc3cc(O)cc(O)c3c(=O)c2O[C@@H]2O[C@@H](C)[C@H](OC(=O)/C=C/c3ccc(O)cc3)[C@@H](O)[C@H]2OC(=O)/C=C\c2ccc(O)cc2)cc1

Basic Information

ChEMBL ID CHEMBL4468168
Phase Preclinical
Structure Type MOL
InChI Key FSJKWOXNSZKWAF-SNEURSICSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

738.7
MW (Da)
5.03
ALogP
14
HBA
5
HBD
211.7
PSA (Ų)
0.09
QED
3
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C40H34O14
MW 738.70
Aromatic Rings 5
Heavy Atoms 54
NP-Likeness 1.34

Activity Summary

IC50 1 meas. best 5.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.0 5.0 10100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 10100.0 nM 5.0 Inhibition of yeast alpha-glucosidase pre-incubated for 10 mins followed by pNPG... 30668111

Literature References

PubMed DOI Target Context # Activities
30668111 10.1021/acs.jnatprod.8b00609 Unchecked 2

Data from ChEMBL 36 via Core Engine