Assay Detail
Functional
CHEMBL4334027
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Induction of adipogenesis in human bone marrow-derived mesenchymal stem cells assessed as increase in adiponectin production measured on day 5 in presence of IDX by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Adiponectin-Secretion-Promoting Phenylethylchromones from the Agarwood of Aquilaria malaccensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.21 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.46 |
| CHEMBL472 | GLYBURIDE | 4.0 | 1 | 5.53 |
| CHEMBL4453254 | — | — | 1 | 4.79 |
| CHEMBL4555353 | — | — | 1 | 4.69 |
| CHEMBL481060 | FLIDERSIACHROMONE | — | 1 | 4.60 |
| CHEMBL4574909 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL472 | GLYBURIDE | EC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4453254 | — | EC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL4555353 | — | EC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL481060 | FLIDERSIACHROMONE | EC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL4574909 | — | EC50 | > | 60000.0 | nM | - |