Compound Detail
CHEMBL481060
FLIDERSIACHROMONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL481060 |
| Name | FLIDERSIACHROMONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VNZNWFQJBFLELF-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
250.3
MW (Da)
3.58
ALogP
2
HBA
0
HBD
30.2
PSA (Ų)
0.71
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.6
Ki 1 meas. best 4.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 4.6 | 4.6 | 25300.0 | 1 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | Ki | 4.27 | 4.27 | 54000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 25300.0 | nM | 4.6 | Induction of adipogenesis in human bone marrow-derived mesenchymal stem cells as... | 30672698 |
| Peroxisome proliferator-activated receptor gamma | Ki | = | 54000.0 | nM | 4.27 | Binding affinity to PPARgamma (unknown origin) by TR-FRET assay | 30672698 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30672698 | 10.1021/acs.jnatprod.8b00635 | Peroxisome proliferator-activated receptor gamma | 3 |
| 30672698 | 10.1021/acs.jnatprod.8b00635 | Unchecked | 2 |
| 16499335 | 10.1021/np0503808 | NON-PROTEIN TARGET | 1 |
| 30672698 | 10.1021/acs.jnatprod.8b00635 | Glucocorticoid receptor | 1 |
| 30672698 | 10.1021/acs.jnatprod.8b00635 | Peroxisome proliferator-activated receptor alpha | 1 |
| 30672698 | 10.1021/acs.jnatprod.8b00635 | Peroxisome proliferator-activated receptor delta | 1 |
| 30672698 | 10.1021/acs.jnatprod.8b00635 | Oxysterols receptor LXR-alpha | 1 |
Data from ChEMBL 36 via Core Engine