Assay Detail
Binding
CHEMBL4334128
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.36 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.48 |
| CHEMBL295124 | BERBERINE | 4.0 | 1 | 6.16 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.77 |
| CHEMBL206106 | PALMITINE | — | 1 | 5.77 |
| CHEMBL4548293 | — | — | 1 | 4.18 |
| CHEMBL4590539 | — | — | 1 | 4.17 |
| CHEMBL452895 | OBAMEGINE | — | 1 | 4.01 |
| CHEMBL79993 | Z-PRO-PROLINAL | — | 1 | - |
| CHEMBL508781 | — | — | 1 | - |
| CHEMBL504323 | BERBAMINE | — | 1 | - |
| CHEMBL4585711 | — | — | 1 | - |
| CHEMBL4434785 | — | — | 1 | - |
| CHEMBL11531 | OXYBERBERINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL295124 | BERBERINE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL206106 | PALMITINE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4548293 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL4590539 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL452895 | OBAMEGINE | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL79993 | Z-PRO-PROLINAL | IC50 | - | — | - | |
| CHEMBL508781 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL504323 | BERBAMINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL4585711 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4434785 | — | IC50 | - | — | - | |
| CHEMBL11531 | OXYBERBERINE | IC50 | > | 100000.0 | nM | - |