Assay Detail
Functional
CHEMBL4334560
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Antiproliferative activity against human SK-N-AS cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-AS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.02 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458544 | — | — | 1 | 6.66 |
| CHEMBL4580143 | — | — | 1 | 6.47 |
| CHEMBL4583725 | — | — | 1 | 6.41 |
| CHEMBL4522149 | — | — | 1 | 6.40 |
| CHEMBL4455083 | — | — | 1 | 6.21 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.16 |
| CHEMBL4539004 | — | — | 1 | 6.04 |
| CHEMBL4476049 | — | — | 1 | 5.85 |
| CHEMBL4549502 | — | — | 1 | 5.76 |
| CHEMBL4461005 | — | — | 1 | 5.73 |
| CHEMBL4577419 | — | — | 1 | 5.48 |
| CHEMBL4562808 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458544 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4580143 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4583725 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4522149 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4455083 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4539004 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4476049 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4549502 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4461005 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL4577419 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL4562808 | — | IC50 | = | 9470.0 | nM | 5.02 |