Assay Detail
Functional
CHEMBL4335392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV pseudotyped virions infected in human HEK293T cells cotransfected with envelope deficient pNL4-3.luc.R-E- plasmid and VSVG plasmid assessed as inhibition of HIV replication preincubated for 15 mins followed by viral infection and measured at 48 hrs post-infection by luciferase based luminescence method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.89 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454780 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454780 | — | EC50 | = | 13.0 | nM | 7.89 |