Assay Detail
Binding
CHEMBL4336751
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Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Integrated Synthetic, Biophysical, and Computational Investigations of Covalent Inhibitors of Prolyl Oligopeptidase and Fibroblast Activation Protein α.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.08 | 9.00 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79993 | Z-PRO-PROLINAL | — | 1 | 9.00 |
| CHEMBL4451993 | — | — | 1 | 8.40 |
| CHEMBL2159748 | — | — | 1 | 7.60 |
| CHEMBL4558566 | — | — | 1 | 6.96 |
| CHEMBL2159749 | — | — | 1 | 6.80 |
| CHEMBL4462021 | — | — | 1 | 6.77 |
| CHEMBL4437462 | — | — | 1 | 6.54 |
| CHEMBL4584206 | — | — | 1 | 6.21 |
| CHEMBL4474579 | — | — | 1 | 5.48 |
| CHEMBL4303429 | — | — | 1 | - |
| CHEMBL4453293 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79993 | Z-PRO-PROLINAL | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4451993 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2159748 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4558566 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2159749 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL4462021 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4437462 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL4584206 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL4474579 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL4303429 | — | Inhibition | - | % | - | |
| CHEMBL4453293 | — | Ki | > | 100000.0 | nM | - |