Assay Detail
Binding
CHEMBL4336753
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Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA substrate and measured every 30 secs for first 60 mins followed by every 2 mins for next 5 hrs by dilution assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Integrated Synthetic, Biophysical, and Computational Investigations of Covalent Inhibitors of Prolyl Oligopeptidase and Fibroblast Activation Protein α.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.25 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79993 | Z-PRO-PROLINAL | — | 1 | 9.40 |
| CHEMBL4451993 | — | — | 1 | 8.46 |
| CHEMBL2159748 | — | — | 1 | 7.60 |
| CHEMBL4558566 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79993 | Z-PRO-PROLINAL | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL4451993 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL2159748 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4558566 | — | Ki | = | 29.0 | nM | 7.54 |