Assay Detail
Binding
CHEMBL4336763
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Inhibition of CK2alpha (unknown origin) using RRRADDSDDDDD as substrate in presence of [gamma33P]-ATP by autoradiography
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule modulators targeting protein kinase CK1 and CK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.60 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 9.42 |
| CHEMBL2087008 | — | — | 1 | 7.50 |
| CHEMBL270724 | — | — | 1 | 7.11 |
| CHEMBL1682283 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL2087008 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL270724 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL1682283 | — | Ki | = | 420.0 | nM | 6.38 |