Compound Detail
CHEMBL270724
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Basic Information
| ChEMBL ID | CHEMBL270724 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SVJQCVOKYJWUBC-OWOJBTEDSA-N |
5
Targets
7
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
463.8
MW (Da)
4.83
ALogP
1
HBA
1
HBD
37.3
PSA (Ų)
0.39
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.96
Ki 2 meas. best 7.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Casein kinase II subunit alpha CHEMBL3629 | Ki | 7.11 | 7.11 | 77.0 | 1 |
| Casein kinase 2 CHEMBL3988629 | Ki | 7.11 | 7.11 | 77.0 | 1 |
| Casein kinase II CHEMBL2095191 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
| Casein kinase 2 CHEMBL3988629 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.96 | 6.96 | 110.0 | 2 |
| Interferon-induced, double-stranded RNA-activated protein kinase CHEMBL5785 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Casein kinase II subunit alpha | Ki | = | 77.0 | nM | 7.11 | Inhibition of CK2alpha (unknown origin) using RRRADDSDDDDD as substrate in prese... | 31400711 |
| Casein kinase 2 | Ki | = | 77.0 | nM | 7.11 | Inhibition of rat liver CK2 phosphorylation using RRRADDSDDDDD as substrate in p... | 36745746 |
| Unchecked | IC50 | = | 110.0 | nM | 6.96 | Inhibition of CK2 in rat liver | 18251491 |
| Casein kinase II | IC50 | = | 110.0 | nM | 6.96 | Inhibition of CK2 (unknown origin) | - |
| Unchecked | IC50 | = | 110.0 | nM | 6.96 | Inhibition of casein kinase-2 in human PASMC incubated for 24 hrs assessed as re... | - |
| Casein kinase 2 | IC50 | = | 110.0 | nM | 6.96 | Inhibition of rat liver CK2 phosphorylation using RRRADDSDDDDD as substrate in p... | 36745746 |
| Interferon-induced, double-stranded RNA-activated protein kinase | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10... | 21632247 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23398362 | 10.1042/bj20121418 | Insulin receptor | 4 |
| 23398362 | 10.1042/bj20121418 | Insulin-like growth factor 1 receptor | 4 |
| 23398362 | 10.1042/bj20121418 | cGMP-dependent protein kinase 1 | 4 |
| 23398362 | 10.1042/bj20121418 | Cyclin-dependent kinase 5/CDK5 activator 1 | 4 |
| 23398362 | 10.1042/bj20121418 | Serine/threonine-protein kinase mTOR | 4 |
| 23398362 | 10.1042/bj20121418 | Protein kinase C beta type | 4 |
| 23398362 | 10.1042/bj20121418 | Tyrosine-protein kinase Lck | 4 |
| 23398362 | 10.1042/bj20121418 | Tyrosine-protein kinase HCK | 4 |
| 23398362 | 10.1042/bj20121418 | Casein kinase I isoform delta | 2 |
| 23398362 | 10.1042/bj20121418 | Cyclin-dependent kinase 2/cyclin E | 2 |
| 23398362 | 10.1042/bj20121418 | Dual specificity mitogen-activated protein kinase kinase 1 | 2 |
| 23398362 | 10.1042/bj20121418 | Inhibitor of nuclear factor kappa-B kinase subunit alpha | 2 |
| 23398362 | 10.1042/bj20121418 | Tyrosine-protein kinase Fyn | 2 |
| 23398362 | 10.1042/bj20121418 | Fibroblast growth factor receptor 3 | 2 |
| 23398362 | 10.1042/bj20121418 | Ephrin type-A receptor 4 | 2 |
| 23398362 | 10.1042/bj20121418 | Calcium/calmodulin-dependent protein kinase type 1D | 2 |
| 36745746 | 10.1021/acs.jmedchem.2c01523 | Casein kinase 2 | 2 |
| 23398362 | 10.1042/bj20121418 | Tyrosine-protein kinase ABL2 | 2 |
| 23398362 | 10.1042/bj20121418 | Serine/threonine-protein kinase Nek7 | 2 |
| 23398362 | 10.1042/bj20121418 | Serine/threonine-protein kinase Nek6 | 2 |
Data from ChEMBL 36 via Core Engine