Assay Detail
Binding
CHEMBL4418596
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Inhibition of casein kinase-2 in human PASMC incubated for 24 hrs assessed as reduction in NkX2-5 nuclear localization by immunofluorescence assay
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitors of nkx2.5 for vascular remodelling
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC80 | 6 | - | - |
| IC50 | 6 | 7.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 2 | 9.00 |
| CHEMBL206524 | — | — | 2 | 8.05 |
| CHEMBL2087023 | — | — | 2 | 7.34 |
| CHEMBL270724 | — | — | 2 | 6.96 |
| CHEMBL29898 | QUINALIZARIN | — | 2 | 6.96 |
| CHEMBL1233807 | — | — | 2 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL206524 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2087023 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL270724 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL29898 | QUINALIZARIN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1233807 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1230165 | SILMITASERTIB | IC80 | = | 1.6 | nM | - |
| CHEMBL270724 | — | IC80 | = | 176.0 | nM | - |
| CHEMBL1233807 | — | IC80 | = | 800.0 | nM | - |
| CHEMBL206524 | — | IC80 | = | 14.4 | nM | - |
| CHEMBL29898 | QUINALIZARIN | IC80 | = | 176.0 | nM | - |
| CHEMBL2087023 | — | IC80 | = | 73.6 | nM | - |